The effect of daclizumab on brain atrophy in relapsing-remitting multiple sclerosis
نویسندگان
چکیده
منابع مشابه
The Effect of Gadolinium Enhancing Lesions on Whole Brain Atrophy in Relapsing-Remitting Multiple Sclerosis
Multiple sclerosis (MS) is a chronic demyelinating disease of the central nervous system. Gadolinium enhancing lesions on Tl-weighted MR images reflect abnormalities in the blood-brain barrier (BBB), and are used as measures of active inflammation. Enhancement has been found to precede the development of chronic lesions and clinical symptoms, suggesting that BBB breakdown may be linked to the d...
متن کاملEffects of disease modifying therapies on brain and grey matter atrophy in relapsing remitting multiple sclerosis
Background: Progressive brain atrophy is a major feature of multiple sclerosis (MS) pathology and is actually considered a major determinant of the progressive accumulation of physical and cognitive disability in MS patients. Although brain atrophy may have different pathological substrates, several lines of evidence suggest that in disease modifying drug (DMD)-treated MS patients, the higher i...
متن کاملReview of daclizumab and its therapeutic potential in the treatment of relapsing–remitting multiple sclerosis
Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system. It can present in several forms, with the relapsing-remitting pattern being the most common. Since the approval of the first disease-modifying therapy and the initiation of appropriate treatments from the early stages of the disease, there seem to be positive impacts on the long-term outcomes ...
متن کاملBrain atrophy in relapsing-remitting multiple sclerosis: fractional volumetric analysis of gray matter and white matter.
PURPOSE To determine the fractional brain tissue volume changes in the gray matter and white matter of patients with relapsing-remitting multiple sclerosis (MS) and to correlate these measurements with clinical disability and total lesion load. MATERIALS AND METHODS Thirty patients with relapsing-remitting MS and 25 healthy control subjects underwent magnetic resonance imaging. Fractional bra...
متن کاملResting State Brain Entropy Alterations in Relapsing Remitting Multiple Sclerosis
Brain entropy (BEN) mapping provides a novel approach to characterize brain temporal dynamics, a key feature of human brain. Using resting state functional magnetic resonance imaging (rsfMRI), reliable and spatially distributed BEN patterns have been identified in normal brain, suggesting a potential use in clinical populations since temporal brain dynamics and entropy may be altered in disease...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Multiple Sclerosis and Related Disorders
سال: 2013
ISSN: 2211-0348
DOI: 10.1016/j.msard.2012.10.002